Botox May Have Long-Lasting, Anti-Aging Effects

May 21, 2015

Botox, an injection that paralyzes facial muscles to reduce the appearance of wrinkles, has a reputation for being the remedy of choice for vain starlets because it’s superficial and fleeting.

But a recent study suggests it may not be quite as superficial or as temporary.

The drug increases skin elasticity for the three to four months that it stays active, according to a Canadian study published in JAMA Facial Plastic Surgery by dermatologist Dr. James Bonaparte of the University of Ottawa and Dr. David Ellis of the University of Toronto.

“The initial theory for Botox was you paralyze the muscle, you then can’t make the wrinkle anymore because you can’t move. This is suggesting that there’s maybe more going on than just that, that you’re actually remodeling the skin to get rid of the wrinkle,” Bonaparte said.

Dermatologists had observed that even deep wrinkles that weren’t erased by Botox became less severe while it was active. Bonaparte has endeavored to measure the effect scientifically.

In the current study, he and Ellis used a Cutometer, a device that sucks the skin and measures how much it rebounds to its previous position. As we age, our skin becomes less elastic, recoiling about 30 percent less at age 70 than it does at age 20.

Flaccid skin makes us look older. It also makes the skin more prone to wrinkle.

The researchers found that when the effects of Botox were at their most powerful, the drug could increase elasticity by 30 percent. The effect peaked at two months and then waned before dropping off at four months.

The researchers tracked 43 women who were using Botox for the first time.

Could Botox Prevent Wrinkles from Forming?
Bonaparte’s earlier work on the same topic was met with criticism. Critics argued that what seemed to be elasticity could simply be swelling as a result of the injury from injection. As the skin heals from injury it draws in more water and becomes more elastic for a week or two.

The current study ruled that out by showing that injury resulted in a different pattern of resistance to the suction.

“Botox might be doing two things, one to the muscle one to the skin,” Bonaparte said.

If indeed Botox makes the skin more elastic, it may also help prevent the formation of wrinkles. That could expand the market for cosmetic injections significantly. More than 6.6 million Americans underwent treatment with Botox or a similar drug last year, according to the American Society of Plastic Surgeons.

Bonaparte, who also works in private practice, performs Botox injections for a fee. His study was funded by Allergan, the pharmaceutical company that makes Botox. All of the research to date on the potential anti-aging effects of Botox has been funded by Allergan, Bonaparte said.

Two other products, Dysport and Xeomin, can also legally be used to mute the furrow between eyebrows. Like Botox, they are derived from the naturally occurring botulinum toxin. Only Botox has the approval of the Food and Drug Administration for use on crow’s feet, but the others are often used off-label.

“There’s not reason to believe the other drugs wouldn’t have the same effect,” Bonaparte said.

To nail down exactly how the botulinum toxins ramp up elasticity, the next step will be to remove small bits of skin from participants before and after the procedures.

Cameron Scott, Healthline News

Repeated Botox Use Improves Patient Satisfaction With No Additional Safety Risk

May 28, 2015

According to the third study in a phase 3 program, repeated Botox treatments of 24 U and 44 U significantly improved glabellar lines and crow’s feet lines as assessed through Facial Wrinkle Scale and patient-reported outcomes.

The multicenter, double-blind, randomized, parallel-group, placebo-controlled study was an extension study of subjects who completed a 7-month phase 3 study, which allowed for up to two additional treatment cycles and up to 1 year of treatment exposure.

Subjects who had received Botox in the first studies continued to receive the same dose in this study: 44 U for crow’s feet lines (CFL) and glabellar lines (GL) or 24 U for CFL alone.

Those who received placebo previously were re-randomized to either 44U for CFL and GL or to placebo in a 1:1 ratio.

Primary end point was the proportion of subjects with a grade of none or mild at maximum smile on Day 30 based on investigator’s Facial Wrinkle Scale ratings, according to researchers.

Patient-reported outcomes included the Subject’s Global Assessment of Change in Crow’s Feet Lines (SGA-CFL), the Facial Line Outcomes Questionnaire (FLO-11), Self Perception of Age and the Subject Satisfaction of Appearance.

A total of 667 subjects received the third treatment and most subjects (80.2%) received the third dose at the first study visit.

The responder ratings at Day 30 in achieving none or mild on Facial Wrinkle Scale for Botox were significantly greater than for placebo treatment, 63.6% for 44 U group, 56.5% for 24 U group and 1.1% for placebo.

At all other time points assessed the BTX-A responder rates were significantly greater.

Botox also showed greater improvement from baseline of at least one grade on the Facial Wrinkle Scale.

Patient-reported outcomes also favored Botox.

The proportion of responders for FLO-11 Items 2, 5 and 8 was significantly greater in the Botox treatment groups than in placebo on Day 30 and up to at least Day 60 in each treatment cycle. For Items 2, 5 and 8 Botox scored 76.3%, 66.0% and 61.4%, respectively, compared with 32.6%, 26.7% and 27.3%, for the corresponding placebo rates.

More Botox patients reported looking younger than their current age, 47.5% in the 44 U group, 38.7% in the 24 U group, vs. 5.1% in the placebo group.

Researchers also found that adverse events did not increase with repeated treatments and no new safety concerns arose.

Abigail Sutton, Healio

Advanced Skin Care for Men

Advanced Skin Care for Men?

Advanced Skin Care for Men

When it comes to skin care, men seem to have it easy. From a very young age, women are inundated with advertisements and information, instructing them on how to care for their skin to retain a youthful, beautiful glow. Women learn the art of cleansing and moisturizing, sun protection and wrinkle minimization. Men, on the other hand, are expected to look great and age gracefully, without support.

This social perception does men a great disservice. Some people do have naturally beautiful, healthy skin early in their lives. Others need support to get the look, feel, and comfort they want. This is true for women. This is true for men. The primary difference is in our attitudes towards the needs of men. Men who work for their great skin know these attitudes don’t have to be a barrier to healthy skin.

The reality for many of us is that truly great looking skin requires a daily skin care routine. We need to cleanse, tone, moisturize, and protect our skin. This helps to keep our skin clear, supple, and healthy. Savvy men learn to perform these tasks, even though they are not the primary target of suppliers.

It’s also true that for many of us, our daily skin care routine is insufficient to provide us with lasting, life-long results. Women have an advantage over their male counterparts, because they are inundated with information and advertisements that increase their awareness of the many options available in the marketplace today. They learn rather early in life that there are advanced skin care options. They come across articles and advertisements that answer the most obvious question: What is “Advanced Skin Care?” So, they learn the answer.

Men often have to dig for this information, but not anymore. Advanced Skin Care refers to a variety of services available through professional practitioners who treat clients’ skin to maximize healthy and appearance while minimizing the ravages of time and natural imbalances. In the past, these practitioners ranged from beauticians or cosmetologists, who performed facials and hair removal, to dermatologist, who specialized in skin health. Now, new practitioners have arisen from our technological and scientific advancements to provide additional services that fall somewhere between these two categories.

These new practitioners have developed products and services that address a variety of skin related problems. You can get advanced acne fighting treatments, as well as age-defying services. The true advantage of these advancements is our new-found ability to maintain the health and well-being of our skin. Weather and aging damages our skin over time. An effective daily skin care routine can minimize some of this damage, by maintain the health and resilience of our skin. Yet the damage still occurs–it’s unavoidable.

Advanced skin care treatments can actually reverse the appearance of damage. For example, Botox® treatments available all across the continent, from Calgary, Alberta to the tip of Florida, can visibly reduce or reverse these signs of ageing to improve the appearance of the skin. These services are not particular to women, but are useful for anyone who wants to improve their appearance and retain their youthful glow. Both topical and traditional Botox® services are available, depending on your advanced skin care needs.

Men shouldn’t let antiquated social attitudes get in the way of the great looking skin they deserve. The benefits of both a daily skin care routine and advanced skin care services are available to everyone. You, too, can get the great-looking, healthy skin you want right here in Calgary.